Kidney cortex mitochondria are non-functional in a potassium-based media whereas heart mitochondria improve with increasing potassium concentration
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چکیده
منابع مشابه
Potassium channels in brain mitochondria.
Potassium channels are the most widely distributed class of ion channels. These channels are transmembrane proteins known to play important roles in both normal and pathophysiological functions in all cell types. Various potassium channels are recognised as potential therapeutic targets in the treatment of Parkinson's disease, Alzheimer's disease, brain/spinal cord ischaemia and sepsis. In addi...
متن کاملActive transport of potassium ion in heart mitochondria.
Several factors affecting K* transport by rabbit heart mitochondria were examined, using a K-sensitive electrode. The histone fractions f2a and j3-7 produced an energy-dependent efflux of K*. Inorganic phosphate was required for optimal activity; Km for phosphate was 60 /AM. Both rate and extent of K + efflux decreased as K concentration in the reaction medium was increased. The direction of va...
متن کاملEndothelial mitochondria as a possible target for potassium channel modulators.
Variety of ion channels is present in plasma membrane of endothelial cells. These include the potassium channels such as Ca(2+)-activated K(+) channels, inwardly rectifying K(+) channels, voltage-dependent K(+) channels and also ATP-regulated K(+) channels. Due to an influence on the membrane potential they are important regulators of vascular tone by modulating endothelial calcium ions signali...
متن کاملEffect of antihypertensive agents - captopril and nifedipine - on the functional properties of rat heart mitochondria
Objective(s): Investigation of acute effect on cellular bioenergetics provides the opportunity to characterize the possible adverse effects of drugs more comprehensively. This study aimed to investigate the changes in biochemical and biophysical properties of heart mitochondria induced by captopril and nifedipine antihypertensive treatment. Materials and Methods: Male, 12-week-old Wistar rats i...
متن کاملThe Stoichiometry of Respiration-driven Potassium Transport in Corn Mitochondria.
Determinations were made for corn (Zea mays L., WF9-Tms x M14) mitochondria of the stoichiometric relationship between K(+) transport and bond energy produced in respiration (K(+)/ approximately ratio). With inward pumping of potassium acetate activated by NADH oxidation, the initial rate of K(+) transported into the sucrose inaccessible space varied between 0.58 and 0.97 K(+)/ approximately , ...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 2010
ISSN: 0005-2728
DOI: 10.1016/j.bbabio.2010.04.404